(19)

(11)

EP 4 493 683 A1

(12)

(43) Date of publication: 22.01.2025 Bulletin 2025/04 (21) Application number: 23716133.6 (22) Date of filing: 15.03.2023

(51) International Patent Classification (IPC):  C12N 9/16(2006.01) C12N 15/00(2006.01) (52) Cooperative Patent Classification (CPC): C12Y 301/02014; C12N 9/16; C12P 7/6436 (86) International application number: PCT/US2023/064461 (87) International publication number: WO 2023/178193 (21.09.2023 Gazette 2023/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 16.03.2022 US 202263320571 P (71) Applicant: Genomatica, Inc. San Diego CA 92121 (US)	(72) Inventors: SCHIRMER, Andreas W. San Diego, California 92121 (US) POPOVA, Emanuela Emilova San Diego, California 92121 (US) WONG, Leland Ken San Diego, California 92121 (US) HOLDEN, Kevin San Diego, California 92121 (US) (74) Representative: KATZAROV S.A.  Geneva Business Center 12 Avenue des Morgines 1213 Petit-Lancy 1213 Petit-Lancy (CH)