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EP 4 499 152 A1

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(43) Date of publication: 05.02.2025 Bulletin 2025/06 (21) Application number: 23717258.0 (22) Date of filing: 28.03.2023

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 9/10(2006.01) C12N 15/113(2010.01) C12N 9/02(2006.01) C12N 9/22(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/86; A61K 48/005; C12N 9/1007; C12N 9/0071; C12N 2750/14143; C12N 2830/006; C12Y 114/11; C12N 15/62; C07K 2319/00; C12N 15/1137; C12N 2310/14; C12Y 204/0203 (86) International application number: PCT/IB2023/053072 (87) International publication number: WO 2023/187639 (05.10.2023 Gazette 2023/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 30.03.2022 IT 202200006296 (71) Applicant: Fondazione Istituto Italiano di Tecnologia 16163 Genova (IT)	(72) Inventors: SERANI, Angelo 16163 GENOVA (IT) TUCCI, Valter 16163 GENOVA (IT) (74) Representative: Studio Torta S.p.A.  Via Viotti, 9 10121 Torino 10121 Torino (IT)