(19)

(11)

EP 4 499 697 A1

(12)

(43) Date of publication: 05.02.2025 Bulletin 2025/06 (21) Application number: 23773420.7 (22) Date of filing: 24.03.2023

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 47/68(2017.01) C12N 15/13(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/28; A61P 35/00; A61K 47/6877; A61K 47/6889; A61K 47/68031; A61K 47/6803; A61K 47/6849; A61K 47/68033; C07K 2317/24; C07K 2317/77; A61K 2039/505; C07K 2317/90; C07K 2317/524; C07K 2317/526; C07K 2317/92; C07K 2317/35; C07K 2317/33; C07K 2317/94; C07K 2317/34; C07K 2317/565 (86) International application number: PCT/CA2023/050405 (87) International publication number: WO 2023/178451 (28.09.2023 Gazette 2023/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 25.03.2022 US 202263323957 P 18.10.2022 US 202263417293 P 07.03.2023 US 202363450602 P (71) Applicant: Zymeworks BC Inc. Vancouver, BC V5T 1G4 (CA)

(72) Inventors: RICH, James R. Vancouver, British Columbia V5T 1G4 (CA) DAVIES, Rupert H. Seattle, Washington 98161 (US) BARNSCHER, Stuart Daniel Vancouver, British Columbia V5T 1G4 (CA) UROSEV, Dunja Vancouver, British Columbia V5T 1G4 (CA) KANG, Sukhbir Singh Vancouver, British Columbia V5T 1G4 (CA) CHAN, Peter Wing Yiu Vancouver, British Columbia V5T 1G4 (CA) DAS, Samir Vancouver, British Columbia V5T 1G4 (CA) HERNANDEZ ROJAS, Andrea Vancouver, British Columbia V5T 1G4 (CA) GENE, Robert William Vancouver, British Columbia V5T 1G4 (CA) YOUNG, Ada G. H. Vancouver, British Columbia V5T 1G4 (CA) LAWN, Samuel Oliver Vancouver, British Columbia V5T 1G4 (CA) CHUI, Danny Vancouver, British Columbia V5T 1G4 (CA) BROWMAN, Duncan Vancouver, British Columbia V5T 1G4 (CA) CLAVETTE, Brandon Vancouver, British Columbia V5T 1G4 (CA) (74) Representative: Elkington and Fife LLP  Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)