(19)

(11)

EP 4 499 820 A1

(12)

(43) Date of publication: 05.02.2025 Bulletin 2025/06 (21) Application number: 23716269.8 (22) Date of filing: 30.03.2023

(51) International Patent Classification (IPC):  C12N 15/10(2006.01) C12N 15/70(2006.01) C12Q 1/68(2018.01) C40B 40/06(2006.01) C12N 15/86(2006.01) C12Q 1/70(2006.01) C12N 7/00(2006.01) C12N 15/74(2006.01) C40B 40/02(2006.01) C40B 50/06(2006.01) C12Q 1/689(2018.01) C07K 14/01(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1093; C12Q 2521/301; C40B 40/06; C40B 40/02; C12N 15/70; C12N 15/74; C12N 7/00; C12N 15/86; C12N 2795/10221; C12N 2795/10243; C12N 2795/10223; C12Q 1/689; C12Q 1/70; C12N 15/1058 (86) International application number: PCT/EP2023/058268 (87) International publication number: WO 2023/187041 (05.10.2023 Gazette 2023/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 30.03.2022 EP 22165491 (71) Applicants: Hun-Ren Biological Research Centre Szeged 6726 Szeged (HU) HCEMM Nonprofit Kft. 6728 Szeged (HU) Ramot at Tel-Aviv University Ltd. 6139201 Tel Aviv (IL)

(72) Inventors: KINTSES, Balint 6728 Szeged (HU) APJOK, Gábor 6726 Szeged (HU) SZAMEL, Mónika 6726 Szeged (HU) SARI, Tóbiás 6728 Szeged (HU) MEHI, Orsolya Katinka 6726 Szeged (HU) QIMRON, Ehud 6139201 Tel Aviv (IL) (74) Representative: Redl, Gerda et al REDL Life Science Patent Attorneys Donau-City-Straße 11 1220 Wien 1220 Wien (AT)