(19)

(11)

EP 4 504 896 A1

(12)

(43) Date of publication: 12.02.2025 Bulletin 2025/07 (21) Application number: 23724362.1 (22) Date of filing: 05.05.2023

(51) International Patent Classification (IPC):  C12M 1/42(2006.01) C12M 1/36(2006.01) C12M 1/34(2006.01) C12M 3/00(2006.01) (52) Cooperative Patent Classification (CPC): C12M 35/04; C12M 41/48; C12M 41/40; C12M 23/44 (86) International application number: PCT/GB2023/051189 (87) International publication number: WO 2023/218166 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 11.05.2022 GB 202206912 (71) Applicant: The University of Sheffield Sheffield S10 2TN (GB)	(72) Inventors: WONG, Tuck Seng Sheffield S1 3JD (GB) RADY, Brooks Joseph Sheffield S1 3JD (GB) TEE, Kang Lan Sheffield S1 3JD (GB) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)