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EP 4 507 736 A1

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(43) Date of publication: 19.02.2025 Bulletin 2025/08 (21) Application number: 23721581.9 (22) Date of filing: 12.04.2023

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) A61K 39/395(2006.01) A61P 35/00(2006.01) A61K 31/4439(2006.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 45/06; A61K 39/3955; A61K 47/6861; A61K 47/6855; A61K 47/6869; A61K 47/6851; A61K 31/506; A61K 31/706; C07K 16/2818; C07K 2317/76; C07K 16/30; C07K 2317/24; A61K 2039/507; A61K 39/39558; A61K 2039/54; A61K 2039/545; C07K 2317/21; A61K 47/68037   C-Sets: A61K 31/506, A61K 2300/00; A61K 31/706, A61K 2300/00; A61K 39/3955, A61K 2300/00; A61K 39/39558, A61K 2300/00; (86) International application number: PCT/US2023/065682 (87) International publication number: WO 2023/201267 (19.10.2023 Gazette 2023/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 13.04.2022 US 202263330700 P 02.08.2022 US 202263370228 P 30.09.2022 US 202263377918 P (71) Applicants: GILEAD SCIENCES, INC. Foster City, California 94404 (US) Arcus Biosciences, Inc. Hayward, CA 94545 (US)

(72) Inventors: ABIDOYE, Oyewale Atherton, California 94027 (US) CHOU, Chih-Chien Foster City, California 94404 (US) GROSSMAN, William J. Danville, California 94506 (US) ORF, Jessica N. Foster City, California 94404 (US) PARK, Joseph Kwang Newbury Park, California 91320 (US) SCHOLLER, Nathalie Pacific Grove, California 93950 (US) SIERECKI, Mitchell R. Foster City, California 94404 (US) (74) Representative: Schnappauf, Georg  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)