(19)
(11) EP 4 511 018 A1

(12)

(43) Date of publication:
26.02.2025 Bulletin 2025/09

(21) Application number: 23725417.2

(22) Date of filing: 21.04.2023
(51) International Patent Classification (IPC): 
A61K 31/352(2006.01)
A61K 45/06(2006.01)
A61P 35/02(2006.01)
 A61K 31/7048(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/7048; A61P 35/02; A61P 35/00; A61K 45/06; A61K 31/352
 
C-Sets:
  1. A61K 31/7048, A61K 2300/00;
  2. A61K 31/352, A61K 2300/00;
(86) International application number:
PCT/IB2023/054098
(87) International publication number:
WO 2023/203535 (26.10.2023 Gazette 2023/43)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 22.04.2022 IT 202200007988

(71) Applicants:
  • Fondazione Istituto Italiano di Tecnologia
    16163 Genova (IT)
  • Alma Mater Studiorum - Universita' Di Bologna
    40126 Bologna (IT)

(72) Inventors:
  • DE VIVO, Marco
    16163 GENOVA (IT)
  • BRINDANI, Nicoletta
    16163 GENOVA (IT)
  • MUNAFO', Federico
    40126 BOLOGNA (IT)
  • NIGRO, Michela
    16163 GENOVA (IT)

(74) Representative: Croce, Valeria 
Jacobacci & Partners S.p.A. Via Senato, 8
20121 Milano
20121 Milano (IT)

   


(54) 4-CHROMONE DERIVATIVES AS N-POLYMERASE INHIBITORS FOR USE IN THE TREATMENT PLATINUM RESISTANT METASTATIC NEOPLASM