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EP 4 514 360 A1

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(43) Date of publication: 05.03.2025 Bulletin 2025/10 (21) Application number: 23795796.4 (22) Date of filing: 27.04.2023

(51) International Patent Classification (IPC):  A61K 31/70(2006.01) A61K 31/025(2006.01) A61K 9/48(2006.01) A61P 29/00(2006.01) A61K 31/33(2006.01) A61K 31/7016(2006.01) A61K 47/12(2006.01) C07D 231/12(2006.01) (52) Cooperative Patent Classification (CPC): C07D 405/14; C07D 309/10; A61K 47/549 (86) International application number: PCT/IL2023/050433 (87) International publication number: WO 2023/209722 (02.11.2023 Gazette 2023/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 28.04.2022 US 202263335978 P (71) Applicants: Rambam Med-Tech Ltd. 3109601 Haifa (IL) TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED 3200004 Haifa (IL)	(72) Inventors: KHAMAYSI, Iyad 16930 Kfar Kana (IL) HADAD, Salim 35379 Haifa (IL) ABASSI, Zaid 3456102 Haifa (IL) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)