(19)
(11) EP 4 514 770 A1

(12)

(43) Date of publication:
05.03.2025 Bulletin 2025/10

(21) Application number: 23722549.5

(22) Date of filing: 26.04.2023
(51) International Patent Classification (IPC): 
C07C 213/10(2006.01)
C07C 217/62(2006.01)
 C07C 215/54(2006.01)
(52) Cooperative Patent Classification (CPC):
C07C 217/62; C07C 213/10; C07C 215/54; C07B 2200/13
 
C-Sets:
C07C 213/10, C07C 217/62;
(86) International application number:
PCT/EP2023/061005
(87) International publication number:
WO 2023/209033 (02.11.2023 Gazette 2023/44)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 26.04.2022 EP 22170017

(71) Applicant: KRKA, d.d., Novo mesto
8000 Novo mesto (SI)

(72) Inventors:
  • TIHI, Jaroslav
    8000 Novo mesto (SI)
  • KRASOVEC, Dusan
    8000 Novo mesto (SI)
  • BEZENSEK, Jure
    8000 Novo mesto (SI)
  • CESEK, Anita
    8000 Novo mesto (SI)
  • ANZIC, Borut
    8000 Novo mesto (SI)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) METHOD FOR CRYSTALLIZING TAPENTADOL INTERMEDIATE, TAPENTADOL INTERMEDIATE OF HIGH PURITY, METHOD OF MAKING TAPENTADOL AND TAPENTADOL OF HIGH PURITY