(19)

(11)

EP 4 514 831 A1

(12)

(43) Date of publication: 05.03.2025 Bulletin 2025/10 (21) Application number: 23797304.5 (22) Date of filing: 27.04.2023

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) A61P 25/30(2006.01) A61K 38/17(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/30; C07K 14/70571; A61K 38/00; A61K 48/005; C12N 5/0619; C12N 2510/00; C12N 2750/14143; C12N 2503/02 (86) International application number: PCT/US2023/020251 (87) International publication number: WO 2023/212230 (02.11.2023 Gazette 2023/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.04.2022 US 202263335249 P (71) Applicant: Howard Hughes Medical Institute Chevy Chase, Maryland 20815-6789 (US)	(72) Inventors: STERNSON, Scott Chevy Chase, Maryland 20815-6789 (US) MAGNUS, Christopher Chevy Chase, Maryland 20815-6789 (US) (74) Representative: Bassil, Nicholas Charles  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)