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EP 4 515 554 A1

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(43) Date of publication: 05.03.2025 Bulletin 2025/10 (21) Application number: 23725513.8 (22) Date of filing: 26.04.2023

(51) International Patent Classification (IPC):  G16H 10/20(2018.01) G16H 50/20(2018.01) G16H 20/10(2018.01) G16H 50/50(2018.01) (52) Cooperative Patent Classification (CPC): G16H 10/20; G16H 20/10; G16H 50/20; G16H 50/50 (86) International application number: PCT/US2023/020068 (87) International publication number: WO 2023/212116 (02.11.2023 Gazette 2023/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 26.04.2022 US 202263335215 P 03.06.2022 WO PCT/US2022/032075 03.06.2022 WO PCT/US2022/032084 (71) Applicants: GE Healthcare Limited Chalfont St. Giles, Buckinghamshire HP8 4SP (GB) Vanderbilt University Nashville, TN 37240 (US)

(72) Inventors: WOLBER, Jan Chalfont, St Giles, Buckinghamshire HP8 4SP (GB) CSERNAI, Eszter Katalin 1138 Budapest (HU) KISS, Zoltán 1138 Budapest (HU) LIPPENSZKY, Levente 1138 Budapest (HU) OSTERMAN, Travis Nashville, Tennessee 37240 (US) PARK, Ben Ho Nashville, Tennessee 37240 (US) SMITH, David Samuel Nashville, Tennessee 37240 (US) FABBRI, Daniel Nashville, Tennessee 37240 (US) HORVÁTH, Gergely 1138 Budapest (HU) LENOUE-NEWTON, Michele Nashville, TN 37240 (US) MITTENDORF, Kathleen Nashville, TN 37240 (US) (74) Representative: Gillott-Jones, Nathan Philip et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)