(19)

(11)

EP 4 518 775 A2

(12)

(88) Date of publication A3: 18.01.2024 (43) Date of publication: 12.03.2025 Bulletin 2025/11 (21) Application number: 23820390.5 (22) Date of filing: 07.06.2023

(51) International Patent Classification (IPC):  A61B 17/3205(2006.01) F16H 55/56(2006.01) F16H 55/36(2006.01) (52) Cooperative Patent Classification (CPC): A61B 2017/00287; A61B 17/02; A61B 2090/064; A61B 2017/00557; A61B 2017/00398; A61B 17/00234 (86) International application number: PCT/US2023/024672 (87) International publication number: WO 2023/239765 (14.12.2023 Gazette 2023/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.06.2022 US 202263349646 P (71) Applicant: Roswell Park Cancer Institute Corporation Buffalo, New York 14263 (US)	(72) Inventor: DEMMY, Todd L. Williamsville, New York 14221 (US) (74) Representative: Dehns  10 Old Bailey London EC4M 7NG London EC4M 7NG (GB)