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EP 4 518 883 A1

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(43) Date of publication: 12.03.2025 Bulletin 2025/11 (21) Application number: 23772127.9 (22) Date of filing: 08.09.2023

(51) International Patent Classification (IPC):  A61K 38/18(2006.01) A61P 9/02(2006.01) C12N 5/10(2006.01) A01K 67/027(2024.01) A61P 9/04(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/18; A61P 9/04; A61P 9/02; A01K 67/027; A01K 2207/30; A01K 2227/105; A01K 2267/0375; A01K 2207/35; A01K 67/0276; A01K 2217/075 (86) International application number: PCT/EP2023/074803 (87) International publication number: WO 2024/052563 (14.03.2024 Gazette 2024/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 08.09.2022 US 202263374942 P (71) Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH 55216 Ingelheim am Rhein (DE) Medizinische Hochschule Hannover 30625 Hannover (DE)

(72) Inventors: WOLLERT, Kai Christoph 30177 Hannover (DE) WANG, Yong 30629 Hannover (DE) (74) Representative: Zwicker, Jörk  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)