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EP 4 519 265 A1

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(43) Date of publication: 12.03.2025 Bulletin 2025/11 (21) Application number: 23725134.3 (22) Date of filing: 03.05.2023

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 35/00(2006.01) C07D 519/00(2006.01) A61K 31/4985(2006.01) (52) Cooperative Patent Classification (CPC): C07D 487/04; C07D 519/00; A61P 35/00 (86) International application number: PCT/EP2023/061672 (87) International publication number: WO 2023/213882 (09.11.2023 Gazette 2023/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 04.05.2022 US 202263338419 P (71) Applicants: Bayer Aktiengesellschaft 51373 Leverkusen (DE) The Broad Institute, Inc. Cambridge, MA 02142 (US) Dana-Farber Cancer Institute, Inc. Boston, Massachusetts 02215 (US)

(72) Inventors: SIEGEL, Stephan 10779 Berlin (DE) HERBERT, Simon Anthony 13467 Berlin (DE) SCHMECK, Carsten 45472 Mülheim (DE) SIEGEL, Franziska 10439 Berlin (DE) MORTIER, Jeremie Xavier G. 12055 Berlin (DE) ZIMMERMANN, Stefanie 40233 Düsseldorf (DE) BRIEM, Hans 28279 Bremen (DE) BADER, Benjamin 13467 Berlin (DE) BÖMER, Ulf 16548 Glienicke (DE) SCHRÖDER, Jens 99425 Weimar (DE) ORSI, Douglas Cambridge, Massachusetts 02142 (US) GREULICH, Heidi Cambridge, Massachusetts 02142 (US) GOULD, Alexandra Cambridge, Massachusetts 02142 (US) MEYERSON, Matthew Boston, Massachusetts 02215 (US) ULRICH, Alexander Konstantin Christian 10179 Berlin (DE) HILLIG, Roman 12159 Berlin (DE) KORR, Daniel 10247 Berlin (DE) LECHNER, Christian 10117 Berlin (DE) EVANS, Laura Somerville, Massachusetts 02143 (US) (74) Representative: BIP Patents  c/o Bayer Intellectual Property GmbH Alfred-Nobel-Straße 50 40789 Monheim am Rhein 40789 Monheim am Rhein (DE)