(19)

(11)

EP 4 519 437 A2

(12)

(88) Date of publication A3: 11.01.2024 (43) Date of publication: 12.03.2025 Bulletin 2025/11 (21) Application number: 23727091.3 (22) Date of filing: 05.05.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7088(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1131; C12N 2310/11; C12N 2310/315; C12N 2310/321 (86) International application number: PCT/IB2023/054702 (87) International publication number: WO 2023/214373 (09.11.2023 Gazette 2023/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.05.2022 EP 22172149 (71) Applicant: Academisch Ziekenhuis Leiden (h.o.d.n. LUMC) 2333 ZA Leiden (NL)	(72) Inventors: VAN ZONNEVELD, Anton Jan 3768 GA SOEST (NL) PRINS, Jurriën 2342 DH Oegstgeest (NL) VAN DER VEER, Eric Peter 2498 AW The Hague (NL) MATTHEE, Bianca 1018 NM Amsterdam (NL) (74) Representative: Nederlandsch Octrooibureau  P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)