(19)

(11)

EP 4 522 181 A1

(12)

(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23803950.7 (22) Date of filing: 10.04.2023

(51) International Patent Classification (IPC):  A61K 33/22(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 33/22 (86) International application number: PCT/TR2023/050333 (87) International publication number: WO 2023/219586 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.05.2022 TR 202207524 (71) Applicant: Yeditepe Universitesi Atasehir/Istanbul (TR)	(72) Inventors: SAHIN, Fikrettin 34755 Atasehir/Istanbul (TR) TURKEL SESLI, Nezaket 34755 Atasehir/Istanbul (TR) TAPSIN GULLUOGLU, Sidika Bostanci Kadikoy/Istanbul (TR) (74) Representative: Sevinç, Cenk  Grup Ofis Marka Patent A.S. Atatürk Bulvari, 211/11 Kavaklidere 06680 Ankara 06680 Ankara (TR)