(19)
(11) EP 4 522 205 A1

(12)

(43) Date of publication:
19.03.2025 Bulletin 2025/12

(21) Application number: 23732781.2

(22) Date of filing: 12.05.2023
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
A61P 37/00(2006.01)
C12N 9/00(2006.01)
C12N 15/88(2006.01)
A61K 39/39(2006.01)
A61P 37/04(2006.01)
C12N 9/12(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 39/39; C12N 15/88; A61P 37/00; A61K 2039/55555; A61K 2039/53; C12N 2770/20034; A61P 31/14; A61K 39/12; C12N 9/1241; C12Y 207/07
(86) International application number:
PCT/US2023/066974
(87) International publication number:
WO 2023/220746 (16.11.2023 Gazette 2023/46)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 13.05.2022 US 202263341987 P

(71) Applicant: Corner Therapeutics, Inc.
Watertown, MA 02472 (US)

(72) Inventors:
  • GOSSELIN, Emily
    Watertown, Massachusetts 02472 (US)
  • ZHIVAKI, Dania
    Watertown, Massachusetts 02472 (US)
  • CHOW, Jonathan
    Watertown, Massachusetts 02472 (US)
  • NIKIFOROV, Anastasia
    Watertown, Massachusetts 02472 (US)
  • SENGUPTA, Debrup
    Watertown, Massachusetts 02472 (US)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) MRNA ENCODING A CONSTITUTIVELY-ACTIVE CYCLIC GMP-AMP SYNTHASE AND LIPID DELIVERY VEHICLES FOR SAME