(19)

(11)

EP 4 522 209 A1

(12)

(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23727473.3 (22) Date of filing: 11.05.2023

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; C12N 2760/18334; C12N 2760/18322; A61P 31/14 (86) International application number: PCT/EP2023/062652 (87) International publication number: WO 2023/217988 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 12.05.2022 EP 22173131 (71) Applicant: MSD International Business GmbH 6005 Luzern (CH)	(72) Inventors: LANGEDIJK, Johannes, Petrus, Maria 2333 CN Leiden (NL) BAKKERS, Mark, Johannes, Gerardus 2333 CN Leiden (NL) RITSCHEL, Tina 2333 CN Leiden (NL) JURASZEK, Jaroslaw 2333 CN Leiden (NL) (74) Representative: Merck Sharp & Dohme LLC  120 Moorgate London EC2M 6UR London EC2M 6UR (GB)