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EP 4 522 223 A1

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(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23802902.9 (22) Date of filing: 09.05.2023

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 16/00(2006.01) A61K 38/00(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/00; A61K 47/6849; A61K 47/6889; A61K 47/68031; A61K 47/68037; C07K 5/0205; C07K 7/06; C07K 16/28; C07K 2317/21; C07K 2317/77; A61K 2039/505; A61P 35/00 (86) International application number: PCT/CN2023/092968 (87) International publication number: WO 2023/217133 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 10.05.2022 WO PCT/CN2022/091860 13.04.2023 CN 202310390683 (71) Applicants: Vivasor, Inc. San Diego, CA 92121 (US) Levena Biopharma US, Inc. San Diego, California 92121 (US) Levena (Suzhou) Biopharma Co., Ltd. Suzhou, Jiangsu 215123 (CN) MULTITUDE THERAPEUTICS INC. Shanghai 200233 (CN)

(72) Inventors: FU, Yanwen San Diego California 92121 (US) KOVACS, Ernest William San Diego California 92121 (US) YANG, Mu San Diego California 92121 (US) MENG, Xun Shanghai 200233 (CN) ZHANG, Yue Shanghai 200233 (CN) LIU, Shu-Hui Shanghai 200233 (CN) ZHU, Peng Suzhou, Jiangsu 215123 (CN) (74) Representative: Script Intellectual Property LLP  Suite J, Anchor House School Close Chandlers Ford Eastleigh, Hampshire SO53 4DY Eastleigh, Hampshire SO53 4DY (GB)