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EP 4 522 605 A1

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(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23728908.7 (22) Date of filing: 05.05.2023

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) A61K 31/4545(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; A61P 35/00 (86) International application number: PCT/US2023/021098 (87) International publication number: WO 2023/219879 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.05.2022 US 202263364402 P (71) Applicant: Eisai R&D Management Co., Ltd. Tokyo 112-8088 (JP)

(72) Inventors: LEE, Hyelee Cambridge, Massachusetts 02140 (US) IOANNIDIS, Stephanos Cambridge, Massachusetts 02140 (US) OMOTO, Kiyoyuki Cambridge, Massachusetts 02140 (US) PRAJAPATI, Sudeep Cambridge, Massachusetts 02140 (US) MATSUMOTO, Fusae Cambridge, Massachusetts 02140 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)