(19)

(11)

EP 4 522 613 A1

(12)

(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23731061.0 (22) Date of filing: 10.05.2023

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) C07D 519/00(2006.01) A61K 31/519(2006.01) C07D 487/04(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 487/04; C07D 471/04; C07D 519/00; A61P 35/00 (86) International application number: PCT/US2023/066834 (87) International publication number: WO 2023/220640 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 10.05.2022 US 202263364470 P 06.10.2022 US 202263378671 P 14.04.2023 US 202363496380 P (71) Applicant: Biotheryx, Inc. San Diego, California 92121 (US)

(72) Inventors: CHOURASIA, Aparajita Hoskote San Diego, California 92129 (US) ERDMAN, Paul E. San Diego, California 92126 (US) FUNG, Leah M. San Diego, California 92129 (US) HUANG, Shenlin San Diego, California 92130 (US) LAM, Imelda San Diego, California 92131 (US) MAJESKI, Hannah San Diego, California 92116 (US) OKANO, Akinori San Diego, California 92126 (US) PAPA, Patrick Carlsbad, California 92008 (US) SAPIENZA, John Vista, California 91913 (US) TORRES, Eduardo San Diego, California 92102 (US) WHITEFIELD, Brandon San Diego, California 92108 (US) (74) Representative: Maiwald GmbH  Grünstraße 25 40212 Düsseldorf 40212 Düsseldorf (DE)