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EP 4 522 761 A1

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(43) Date of publication: 19.03.2025 Bulletin 2025/12 (21) Application number: 23803918.4 (22) Date of filing: 06.05.2023

(51) International Patent Classification (IPC):  C12Q 1/04(2006.01) C12Q 1/6851(2018.01) A61P 9/00(2006.01) C12Q 1/689(2018.01) A61K 35/741(2015.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): C12Q 1/689; C12Q 1/6883; A61P 9/00 (86) International application number: PCT/QA2023/050005 (87) International publication number: WO 2023/219522 (16.11.2023 Gazette 2023/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 09.05.2022 US 202263339698 P (71) Applicant: Sidra Medical And Research Center Doha (QA)	(72) Inventors: AL KHODOR, Souhaila 26999 Doha (QA) MURUGESAN, Selvasankar 26999 Doha (QA) EL ANBARI, Mohammed 26999 Doha (QA) TERRANEGRA, Annalisa 26999 Doha (QA) (74) Representative: K&L Gates LLP  Friedrichstraße 110 A 10117 Berlin 10117 Berlin (DE)