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EP 4 529 463 A2

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(88) Date of publication A3: 02.08.2024 (43) Date of publication: 02.04.2025 Bulletin 2025/14 (21) Application number: 23913335.8 (22) Date of filing: 28.12.2023

(51) International Patent Classification (IPC):  A61K 35/00(2006.01) A61L 27/18(2006.01) (52) Cooperative Patent Classification (CPC): A61L 27/26; A61L 27/3834; A61L 27/58; A61L 2430/14; A61L 2400/12; A61K 35/28   C-Sets: A61L 27/26, C08L 67/04; A61L 27/26, C08L 5/00; A61L 27/26, C08L 5/04; (86) International application number: PCT/TR2023/051805 (87) International publication number: WO 2024/144740 (04.07.2024 Gazette 2024/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 30.12.2022 TR 202221899 (71) Applicants: Yildiz Teknik Universitesi 34220 Esenler/ Istanbul (TR) Istanbul Üniversitesi - Cerrahpasa 34320 Avcilar/Istanbul (TR)

(72) Inventors: ALLAHVERD YEV, Adil 34220 Esenler/Istanbul (TR) DERMAN, Serap 34220 Esenler/Istanbul (TR) ABAMOR, Emrah efik 34220 Esenler/Istanbul (TR) BATIO LU KARAALTIN, Aysegül 34320 Avcilar/ stanbul (TR) AKGÜL, Busra 34220 Esenler/Istanbul (TR) (74) Representative: Sevinç, Cenk  Grup Ofis Marka Patent A.S. Atatürk Bulvari, 211/11 Kavaklidere 06680 Ankara 06680 Ankara (TR)