(19)
(11) EP 4 531 873 A1

(12)

(43) Date of publication:
09.04.2025 Bulletin 2025/15

(21) Application number: 23816798.5

(22) Date of filing: 02.06.2023
(51) International Patent Classification (IPC): 
A61K 35/12(2015.01)
A61P 3/10(2006.01)
C12N 5/071(2010.01)
C12N 15/11(2006.01)
 A61K 38/16(2006.01)
A61P 5/50(2006.01)
C12N 5/074(2010.01)
A61K 35/39(2015.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/39; A61P 3/10; A61P 5/50; C12N 5/0679; C12N 2510/00; A61K 35/38
(86) International application number:
PCT/US2023/024294
(87) International publication number:
WO 2023/235568 (07.12.2023 Gazette 2023/49)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 03.06.2022 US 202263348610 P

(71) Applicant: Cornell University
Ithaca, NY 14850 (US)

(72) Inventors:
  • ZHOU, Qiao Joe
    Ithaca, New York 14850 (US)
  • HUANG, Xiaofeng
    Ithaca, New York 14850 (US)

(74) Representative: Reddie & Grose LLP 
The White Chapel Building 10 Whitechapel High Street
London E1 8QS
London E1 8QS (GB)

   


(54) DERIVATION OF GLUCOSE-RESPONSIVE INSULIN-SECRETING CELLS AND ORGANOIDS FROM HUMAN STOMACH CELLS AND THEIR USE TO TREAT DIABETES