(19)
(11) EP 4 532 493 A1

(12)

(43) Date of publication:
09.04.2025 Bulletin 2025/15

(21) Application number: 23734721.6

(22) Date of filing: 30.05.2023
(51) International Patent Classification (IPC): 
C07D 417/14(2006.01)
A61K 31/4436(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; C07D 417/14
(86) International application number:
PCT/IB2023/055539
(87) International publication number:
WO 2023/233295 (07.12.2023 Gazette 2023/49)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 01.06.2022 US 202263365628 P

(71) Applicants:
  • Ideaya Biosciences, Inc.
    South San Francisco, California 94080 (US)
  • GlaxoSmithKline Intellectual Property (No.4) Limited
    Stevenage SG1 2NY (GB)

(72) Inventors:
  • ADAMS, Nicholas
    Collegeville, Pennsylvania 19426 (US)
  • BOTYANSZKI, Janos
    Collegeville, Pennsylvania 19426 (US)
  • DUFFY, Kevin
    Collegeville, Pennsylvania 19426 (US)
  • WANG, Chenbo
    San Francisco, California 94080 (US)
  • FISCHER, Marcus Michael
    san francisco, California 94080 (US)
  • MASKEY, Reeja
    San Francisco, California 94080 (US)

(74) Representative: Coggins, Julia Frances 
GSK Legal & Compliance - Global Patents 79 New Oxford Street
London WC1A 1DG
London WC1A 1DG (GB)

   


(54) THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF