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EP 4 536 282 A2

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(88) Date of publication A3: 29.02.2024 (43) Date of publication: 16.04.2025 Bulletin 2025/16 (21) Application number: 23824455.2 (22) Date of filing: 09.06.2023

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61P 35/00(2006.01) A61K 39/00(2006.01) C12N 5/10(2006.01) C07K 14/705(2006.01) C12N 15/62(2006.01) A61K 35/17(2025.01) (52) Cooperative Patent Classification (CPC): C07K 14/7051; C07K 2319/03; A61P 35/00; A61K 40/4256; A61K 40/31; A61K 40/11 (86) International application number: PCT/US2023/024956 (87) International publication number: WO 2023/244511 (21.12.2023 Gazette 2023/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 13.06.2022 US 202263351746 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: DEMETRIOU, Michael Oakland, California 94607-5200 (US) ZHOU, Raymond Wenhou Oakland, California 94607-5200 (US) ZHU, Yanni Oakland, California 94607-5200 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)