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EP 4 536 639 A1

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(43) Date of publication: 16.04.2025 Bulletin 2025/16 (21) Application number: 23820421.8 (22) Date of filing: 07.06.2023

(51) International Patent Classification (IPC):  C07D 215/22(2006.01) A61K 31/47(2006.01) A61P 33/00(2006.01) C07D 403/04(2006.01) A61K 31/4704(2006.01) (52) Cooperative Patent Classification (CPC): A61P 33/00; C07D 215/22; C07D 403/10; C07D 409/10; C07D 401/10 (86) International application number: PCT/US2023/024746 (87) International publication number: WO 2023/239811 (14.12.2023 Gazette 2023/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.06.2022 US 202263349930 P (71) Applicants: Oregon Health & Science University Portland, OR 97239 (US) The United States Government As Represented By The Dept Of Veterans Affairs Washington, DC 20420 (US)

(72) Inventors: RISCOE, Michael, K. Portland, OR 97239 (US) NILSEN, Aaron Portland, OR 97239 (US) DOGGETT, J. Stone Portland, OR 97239 (US) ALDAY, Holland Portland, OR 97239 (US) LIEBMAN, Katherine Portland, OR 97239 (US) POU, Sovitj Portland, OR 97239 (US) DODEAN, Rozalia Portland, OR 97239 (US) WINTER, Rolf W. Portland, OR 97239 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)