(19)

(11)

EP 4 539 744 A1

(12)

(43) Date of publication: 23.04.2025 Bulletin 2025/17 (21) Application number: 23824464.4 (22) Date of filing: 12.06.2023

(51) International Patent Classification (IPC):  A61B 5/383(2021.01) A61B 5/00(2006.01) A61B 5/374(2021.01) (52) Cooperative Patent Classification (CPC): A61B 5/374; A61B 5/383; A61B 5/4821 (86) International application number: PCT/US2023/025038 (87) International publication number: WO 2023/244528 (21.12.2023 Gazette 2023/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 17.06.2022 US 202263366562 P (71) Applicants: Wisconsin Alumni Research Foundation Madison, WI 53726 (US) University of Milan 20122 Milano (IT) Tiny Blue Dot, Inc. Santa Monica, CA 90401 (US)

(72) Inventors: TONONI, Giulio Verona, WI 53593 (US) KOCH, Christof Pasadena, CA 91106 (US) MASSIMINI, Marcello 20122 Milan (IT) CASAROTTO, Silvia 20122 Milan (IT) COLOMBO, Michele Angelo 20122 Milan (IT) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)