(19)
(11) EP 4 539 871 A1

(12)

(43) Date of publication:
23.04.2025 Bulletin 2025/17

(21) Application number: 23823403.3

(22) Date of filing: 14.06.2023
(51) International Patent Classification (IPC): 
A61K 38/30(2006.01)
A61K 38/08(2019.01)
A61K 31/713(2006.01)
A61K 47/30(2006.01)
 C07K 14/65(2006.01)
A61K 48/00(2006.01)
A61P 25/28(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/713; A61K 38/30; A61P 25/28; C07K 14/65; C12N 2750/14143; C12N 2830/008; C12N 15/86; C12N 2800/30; A01K 2217/075; A01K 2227/105; A01K 2267/0306; A61K 48/005; A01H 5/10
(86) International application number:
PCT/IL2023/050612
(87) International publication number:
WO 2023/242844 (21.12.2023 Gazette 2023/51)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 15.06.2022 US 202263352532 P

(71) Applicant: Ramot at Tel-Aviv University Ltd.
6139201 Tel Aviv (IL)

(72) Inventors:
  • SLUTSKY, Inna
    6139201 Tel Aviv (IL)
  • KATSENELSON, Maxim
    6139201 Tel Aviv (IL)

(74) Representative: ABG Intellectual Property Law, S.L. 
Avenida de Burgos, 16D Edificio Euromor
28036 Madrid
28036 Madrid (ES)

   


(54) METHOD AND THERAPEUTIC AGENT FOR TREATMENT OF DISEASE OR DISORDER ASSOCIATED WITH IMPAIRED FIRING RATE AND/OR MITOCHONDRIAL CALCIUM HOMEOSTASIS