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EP 4 540 285 A1

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(43) Date of publication: 23.04.2025 Bulletin 2025/17 (21) Application number: 22970346.7 (22) Date of filing: 28.12.2022

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/39(2006.01) A61K 39/00(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61K 2039/505; C07K 16/286; C07K 2317/24; C07K 2317/92; C07K 2317/90; C07K 2317/77 (86) International application number: PCT/US2022/082472 (87) International publication number: WO 2024/144803 (04.07.2024 Gazette 2024/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (71) Applicants: Development Center for Biotechnology New Taipei City 22180 (TW) National Health Research Institutes Miaoli County 35053 (TW)

(72) Inventors: YU, Cheng-Chou Taipei City, 22180 (TW) YEH, Shu-Ping Taipei City, 22180 (TW) HUANG, Chao-Yang Taipei City, 115721 (TW) LAI, Szu-Liang Taipei City, 115721 (TW) HSIAO, Shih-Liang Taipei City, 115721 (TW) HOU, Mei-Ling Taipei City, 11571 (TW) YANG, Tzung-Jie Taipei City, 11571 (TW) SUN, Wei-Ting Taipei City, 11571 (TW) HSIA, Liang-Yu Taipei City, 11571 (TW) YUEH, Andrew Miaoli County, 35053 (TW) CHEN, Chiung-Tong Miaoli County, 35053 (TW) WU, Ren-Huang Miaoli County, 35053 (TW) WU, Pei-Shan Miaoli County, 35053 (TW) HU, Han-Shu Miaoli County, 35053 (TW) WU, Tzu-Chin Miaoli County, 35053 (TW) TIAN, Jia-Ni Miaoli County, 35053 (TW) (74) Representative: 2K Patentanwälte Blasberg Kewitz & Reichel  Partnerschaft mbB Schumannstrasse 27 60325 Frankfurt am Main 60325 Frankfurt am Main (DE)