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EP 4 543 461 A1

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(43) Date of publication: 30.04.2025 Bulletin 2025/18 (21) Application number: 23830222.8 (22) Date of filing: 27.06.2023

(51) International Patent Classification (IPC):  A61K 31/712(2006.01) C12N 15/113(2010.01) C07H 19/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; C12N 2310/11; C12N 2310/315; C12N 2310/341; C12N 2310/3515; C12N 2320/32; C12N 2310/3231; C12N 2310/3341; C12N 2320/11; C12N 2320/33; C07H 21/00; A61K 47/54; A61K 47/545; A61K 47/542   C-Sets: C12N 2310/321, C12N 2310/3525; (86) International application number: PCT/CN2023/102618 (87) International publication number: WO 2024/002045 (04.01.2024 Gazette 2024/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 27.06.2022 WO PCT/CN2022/101636 11.08.2022 WO PCT/CN2022/111702 07.12.2022 WO PCT/CN2022/137154 (71) Applicant: Aoan Biosciences Suzhou, Jiangsu 215000 (CN)	(72) Inventors: GAN, Zubao Nantong, Jiangsu 226400 (CN) LI, Longcheng Nantong, Jiangsu 226400 (CN) KANG, Moorim Nantong, Jiangsu 226400 (CN) (74) Representative: Høiberg P/S  Adelgade 12 1304 Copenhagen K 1304 Copenhagen K (DK)