(19)
(11) EP 4 543 482 A2

(12)

(88) Date of publication A3:
08.02.2024

(43) Date of publication:
30.04.2025 Bulletin 2025/18

(21) Application number: 23734655.6

(22) Date of filing: 22.06.2023
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
C07K 14/725(2006.01)
C12N 15/113(2010.01)
 C07K 16/28(2006.01)
C07K 16/18(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 2239/15; A61K 2239/24; A61K 2239/48; C07K 14/7051; C07K 2319/03; C07K 16/18; C07K 16/2866; C07K 2317/31; C07K 2317/622; C07K 2319/40; C12N 2310/20; C12N 15/113; A61K 40/4217; A61K 40/11; A61K 40/31; A61K 40/50
(86) International application number:
PCT/EP2023/067034
(87) International publication number:
WO 2023/247727 (28.12.2023 Gazette 2023/52)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 23.06.2022 EP 22180820
17.04.2023 EP 23168261

(71) Applicant: AvenCell Therapeutics Inc.
Watertown, MA 02472 (US)

(72) Inventors:
  • EHNINGER, Dr. Armin
    01307 Dresden (DE)
  • CARTELLIERI, Marc
    01307 Dresden (DE)
  • LESCARBEAU, Reynald
    Cambridge, Massachusetts 02138 (US)
  • EHNINGER, Gerhard
    01307 Dresden (DE)
  • SCHIERMEIER, Andrew
    Cambridge, MA 02138 (US)

(74) Representative: Kailuweit & Uhlemann Patentanwälte Partnerschaft mbB 
Bamberger Straße 49
01187 Dresden
01187 Dresden (DE)

   


(54) ENGINEERED HUMAN T CELLS COMPRISING A SWITCHABLE CHIMERIC ANTIGEN CELL SURFACE RECEPTOR AND METHODS FOR GENERATING THEM