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(11)

EP 4 543 488 A2

(12)

(88) Date of publication A3: 25.04.2024 (43) Date of publication: 30.04.2025 Bulletin 2025/18 (21) Application number: 23858335.5 (22) Date of filing: 25.08.2023

(51) International Patent Classification (IPC):  A61K 39/39(2006.01) C07K 16/22(2006.01) C07K 16/32(2006.01) A61P 37/02(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2827; C07K 2317/569; C07K 2317/22; C07K 2317/92; C07K 2317/24; C07K 16/22; C07K 2317/31; C07K 2317/76; A61K 2039/505; A61K 2039/507; A61P 35/00 (86) International application number: PCT/US2023/072884 (87) International publication number: WO 2024/044732 (29.02.2024 Gazette 2024/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 25.08.2022 US 202263401086 P (71) Applicant: Bright Biologics LLC Lewes, DE 19958 (US)	(72) Inventors: YANG, Ming Mountain View, California 93043 (US) ZHONG, Hongyan Mountain View, California 94040 (US) LI, Hsieh Mountain View, California 94043 (US) GUO, Daniel San Jose, California 95132 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)