(19)

(11)

EP 4 543 924 A2

(12)

(88) Date of publication A3: 01.02.2024 (43) Date of publication: 30.04.2025 Bulletin 2025/18 (21) Application number: 23742567.3 (22) Date of filing: 21.06.2023

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 47/68(2017.01) A61P 29/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2803; C07K 2317/21; C07K 2317/33; C07K 2317/92; A61P 29/00; A61K 47/6803; A61K 47/6849 (86) International application number: PCT/US2023/068763 (87) International publication number: WO 2023/250341 (28.12.2023 Gazette 2023/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 22.06.2022 US 202263354445 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46206-6288 (US)

(72) Inventors: ANDREWS, Forest Hoyt Indianapolis, Indiana 46206-6288 (US) CLAYTON, Joshua Ryan Indianapolis, Indiana 46206-6288 (US) FELLOWS, Ross Edward Indianapolis, Indiana 46206-6288 (US) MA, Bo Indianapolis, Indiana 46206-6288 (US) TANG, Ying Indianapolis, Indiana 46206-6288 (US) WURST, Jacqueline Mary Indianapolis, Indiana 46206-6288 (US) YACHI, Pia Pauliina Indianapolis, Indiana 46206-6288 (US) YANG, Chiao-Wen Indianapolis, Indiana 46206-6288 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)