(19)

(11)

EP 4 544 052 A1

(12)

(43) Date of publication: 30.04.2025 Bulletin 2025/18 (21) Application number: 23827986.3 (22) Date of filing: 20.06.2023

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61P 1/16(2006.01) C12N 15/63(2006.01) A61K 31/713(2006.01) A61P 9/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/10; A61P 1/16; C12N 15/1137; C12Y 203/01015; C12N 2310/14; C12N 2310/315; C12N 2310/343; C12N 2310/344; A61K 31/7125   C-Sets: C12N 2310/322, C12N 2310/3533; C12N 2310/321, C12N 2310/3521; C12N 2310/321, C12N 2310/3525; (86) International application number: PCT/US2023/068741 (87) International publication number: WO 2023/250327 (28.12.2023 Gazette 2023/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 21.06.2022 US 202263354115 P 16.12.2022 US 202263433365 P (71) Applicant: EMPIRICO INC. San Diego, CA 92122 (US)

(72) Inventors: GOTTESMAN, Omri San Diego, California 92122 (US) BRANDT, Emma San Diego, California 92122 (US) BRUSE, Shannon San Diego, California 92122 (US) CAJES, Brian San Diego, California 92122 (US) JAKUBOSKY, David San Diego, California 92122 (US) LEWIS, David San Diego, California 92122 (US) MCINNES, Gregory San Diego, California 92122 (US) VEKICH, John San Diego, California 92122 (US) ROZEMA, David San Diego, California 92122 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)