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EP 4 544 068 A1

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(43) Date of publication: 30.04.2025 Bulletin 2025/18 (21) Application number: 24736463.1 (22) Date of filing: 01.07.2024

(51) International Patent Classification (IPC):  C12N 15/867(2006.01) C07K 14/145(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2740/16043; C12N 2740/16045; C12N 2740/16052; C12N 2830/008; C07K 14/005; C07K 14/7051; C07K 2319/03; C07K 2317/569; C07K 2319/33; C07K 2319/74; C12N 2740/13043; C12N 2740/13045; C07K 16/2809; C07K 16/2815; C07K 2317/70; C12N 2760/20222   C-Sets: A61K 39/395, A61K 2300/00; (86) International application number: PCT/EP2024/068518 (87) International publication number: WO 2025/003526 (02.01.2025 Gazette 2025/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.06.2023 EP 23182836 (71) Applicant: EsoBiotec 1435 Mont-Saint-Guibert (BE)

(72) Inventors: PARONE, Philippe 1435 Mont-Saint-Guibert (BE) LATERE, Jean-Pierre 1435 Mont-Saint-Guibert (BE) DOIX, Bastien 1435 Mont-Saint-Guibert (BE) GALVIS, Laura 1435 Mont-Saint-Guibert (BE) WEBSTER, Brian 1435 Mont-Saint-Guibert (BE) ABI HABIB, Joanna 1435 Mont-Saint-Guibert (BE) DRAPPIER, Melissa 1435 Mont-Saint-Guibert (BE) FIÉVET, Alexia 1435 Mont-Saint-Guibert (BE) WEERENS, Laura 1435 Mont-Saint-Guibert (BE) PECENKO, Sylvia 1435 Mont-Saint-Guibert (BE) (74) Representative: Schlich  9 St Catherine's Road Littlehampton West Sussex BN17 5HS West Sussex BN17 5HS (GB)