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EP 4 547 287 A2

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(88) Date of publication A3: 07.03.2024 (43) Date of publication: 07.05.2025 Bulletin 2025/19 (21) Application number: 23832664.9 (22) Date of filing: 03.07.2023

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 15/113(2010.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/395; C07K 16/30; C07K 2317/76; C07K 2317/34; C07K 16/2818   C-Sets: A61K 39/395, A61K 2300/00; (86) International application number: PCT/US2023/069585 (87) International publication number: WO 2024/007035 (04.01.2024 Gazette 2024/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 01.07.2022 US 202263357888 P (71) Applicant: Washington University St. Louis, Missouri 63130 (US)

(72) Inventors: CHOI, Kyunghee St. Louis, Missouri 63130 (US) FREMONT, Daved St. Louis, Missouri 63130 (US) KABIR, Ashraf Ul St. Louis, Missouri 63130 (US) KIM, Yeram St. Louis, Missouri 63130 (US) KRCHMA, Karen St. Louis, Missouri 63130 (US) NELSON, A. Christopher St. Louis, Missouri 63130 (US) KWON, Yoojung St. Louis, Missouri 63130 (US) (74) Representative: Greaves Brewster LLP  Copa House Station Road Cheddar, Somerset BS27 3AH Cheddar, Somerset BS27 3AH (GB)