(19)
(11) EP 4 547 701 A1

(12)

(43) Date of publication:
07.05.2025 Bulletin 2025/19

(21) Application number: 23748367.2

(22) Date of filing: 30.06.2023
(51) International Patent Classification (IPC): 
C07K 14/54(2006.01)
A61P 35/00(2006.01)
A61K 38/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 14/5434; A61P 35/00; A61K 38/00; C07K 2319/21; C07K 2319/30; A61K 45/06
(86) International application number:
PCT/US2023/026802
(87) International publication number:
WO 2024/006563 (04.01.2024 Gazette 2024/01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 01.07.2022 US 202263357939 P

(71) Applicant: Sutro Biopharma, Inc.
South San Francisco CA 94080 (US)

(72) Inventors:
  • YANG, Junhao
    South San Francisco, California 94080 (US)
  • GAKHAL, Amandeep Kaur
    South San Francisco, California 94080 (US)
  • YAM, Alice
    South San Francisco, California 94080 (US)
  • CALARESE, Daniel
    South San Francisco, California 94080 (US)
  • HENNINGSEN, Robert
    South San Francisco, California 94080 (US)

(74) Representative: Hutter, Anton et al
Venner Shipley LLP 5 Stirling House Stirling Road The Surrey Research Park
Guildford GU2 7RF
Guildford GU2 7RF (GB)

   


(54) IL-12 MUTANTS WITH REDUCED TOXICITY, COMPOSITIONS THEREOF AND METHODS OF USING THE SAME