(19)

(11)

EP 4 551 015 A2

(12)

(88) Date of publication A3: 29.02.2024 (43) Date of publication: 14.05.2025 Bulletin 2025/20 (21) Application number: 23836005.1 (22) Date of filing: 29.06.2023

(51) International Patent Classification (IPC):  A01N 1/00(2006.01) C12N 5/07(2010.01) (52) Cooperative Patent Classification (CPC): C12N 2529/00; C12N 2523/00; C12N 5/0068; H05B 1/025; A01N 1/142; A01N 1/147 (86) International application number: PCT/US2023/026539 (87) International publication number: WO 2024/010730 (11.01.2024 Gazette 2024/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.07.2022 US 202263358377 P (71) Applicant: Regents of the University of Minnesota Minneapolis, Minnesota 55455-2020 (US)	(72) Inventors: ZHAN, Li Minneapolis, Minnesota 55455 (US) HAN, Zonghu Minneapolis, Minnesota 55455 (US) SHAO, Qi Minneapolis, Minnesota 55455 (US) ETHERIDGE, Michael L. Minneapolis, Minnesota 55455 (US) BISCHOF, John C. Minneapolis, Minnesota 55455 (US) (74) Representative: Peel, James Peter  J.P. Peel & Co Ltd 5 Kew Road Richmond, Surrey TW9 2PR Richmond, Surrey TW9 2PR (GB)