(19)

(11)

EP 4 551 218 A2

(12)

(88) Date of publication A3: 15.02.2024 (43) Date of publication: 14.05.2025 Bulletin 2025/20 (21) Application number: 23836235.4 (22) Date of filing: 05.07.2023

(51) International Patent Classification (IPC):  A61K 31/44(2006.01) A61K 31/166(2006.01) A61K 31/33(2006.01) A61K 31/415(2006.01) A61K 31/167(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; C07D 413/14; A61P 35/00; C07D 417/14 (86) International application number: PCT/US2023/069627 (87) International publication number: WO 2024/011116 (11.01.2024 Gazette 2024/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 07.07.2022 US 202263367875 P (71) Applicant: Dana-Farber Cancer Institute, Inc. Boston, Massachusetts 02215 (US)	(72) Inventor: HATCHER, John M. Boston, Massachusetts 02215 (US) (74) Representative: Elkington and Fife LLP  Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)