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EP 4 551 230 A2

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(88) Date of publication A3: 18.04.2024 (43) Date of publication: 14.05.2025 Bulletin 2025/20 (21) Application number: 23836249.5 (22) Date of filing: 05.07.2023

(51) International Patent Classification (IPC):  A61K 31/7088(2006.01) A61P 21/00(2006.01) A61K 38/40(2006.01) A61K 31/712(2006.01) C12N 15/113(2010.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; C07K 16/2881; C07K 2317/55; C07K 2317/77; A61K 2039/505; A61K 47/6849; A61K 47/6807; C12N 2310/14; C12N 2310/3513; C12N 2310/315; C12N 2320/11; C12N 2320/32; A61K 47/65; A61K 47/6889   C-Sets: C12N 2310/322, C12N 2310/3533; C12N 2310/321, C12N 2310/3521; (86) International application number: PCT/US2023/069652 (87) International publication number: WO 2024/011135 (11.01.2024 Gazette 2024/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.07.2022 US 202263367783 P 23.12.2022 US 202263477160 P (71) Applicant: Dyne Therapeutics, Inc. Waltham MA 02451 (US)

(72) Inventors: HSIA, Nelson Waltham, MA 02451 (US) WEEDEN, Timothy Waltham, MA 02451 (US) ZANOTTI, Stefano Waltham, MA 02451 (US) BESKROVNAYA, Oxana Waltham, MA 02451 (US) DECKERT, Jochen 95444 Bayreuth (DE) VORNLOCHER, Hans-Peter 95326 Kulmbach (DE) SUBRAMANIAN, Romesh, R. Framingham, MA 01701 (US) QATANANI, Mohammed, T. Waltham, MA 02451 (US) DESJARDINS, Cody, A. Waltham, MA 02451 (US) QUINN, Brendan Boston, MA 02118 (US) NAJIM, John Waltham, MA 02451 (US) HOSSBACH, Markus 95326 Kulmbach (DE) HULTSCH, Kathrin 95326 Kulmbach (DE) QIU, Qifeng Waltham, MA 02451 (US) HILDERBRAND, Scott Waltham, MA 02451 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)