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EP 4 551 251 A2

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(88) Date of publication A3: 07.03.2024 (43) Date of publication: 14.05.2025 Bulletin 2025/20 (21) Application number: 23836258.6 (22) Date of filing: 06.07.2023

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 14/47(2006.01) C07K 16/28(2006.01) A61P 21/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6849; A61K 47/6807; C07K 16/2881; C07K 2317/54; C07K 2319/00; A61K 2039/505; A61K 2039/545; C12N 15/1138; C12N 15/113; C12N 2310/11; C12N 2310/315; C12N 2310/322; C12N 2310/341; C12N 2310/346; C12N 2310/3513; C12N 2310/3341; C12N 2310/3231   C-Sets: C12N 2310/322, C12N 2310/3525; (86) International application number: PCT/US2023/069671 (87) International publication number: WO 2024/011150 (11.01.2024 Gazette 2024/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 06.07.2022 US 202263367814 P 14.04.2023 US 202363496184 P (71) Applicant: Dyne Therapeutics, Inc. Waltham MA 02451 (US)

(72) Inventors: MCNEILL, Jonathan Waltham, MA 02451 (US) ZANOTTI, Stefano Waltham, MA 02451 (US) TANG, Kim Waltham, MA 02451 (US) CUI, Jin Waltham, MA 02451 (US) CORREIA, Susana Waltham, MA 02451 (US) BESKROVNAYA, Oxana Waltham, MA 02451 (US) SUBRAMANIAN, Romesh, R. Framingham, MA 01701 (US) QATANANI, Mohammed, T. Waltham, MA 02451 (US) WEEDEN, Timothy Waltham, MA 02451 (US) DESJARDINS, Cody, A. Waltham, MA 02451 (US) QUINN, Brendan Waltham, MA 02451 (US) NAJIM, John Waltham, MA 02451 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)