(19)

(11)

EP 4 551 691 A1

(12)

(43) Date of publication: 14.05.2025 Bulletin 2025/20 (21) Application number: 23748117.1 (22) Date of filing: 05.07.2023

(51) International Patent Classification (IPC):  C12N 5/0775(2010.01) (52) Cooperative Patent Classification (CPC): C12N 5/0663; C12N 5/0665; C12N 5/0636; G01N 33/6863; C12N 5/0662; C12N 5/0669; A61K 35/28; G01N 33/5008; G01N 33/5073; G01N 2333/7155; A61P 37/00 (86) International application number: PCT/IB2023/056939 (87) International publication number: WO 2024/009226 (11.01.2024 Gazette 2024/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 05.07.2022 AU 2022901890 (71) Applicant: Mesoblast International Sàrl 1217 Meyrin (CH)	(72) Inventors: ITESCU, Silviu Melbourne, Victoria 3000 (AU) SIMMONS, Paul Melbourne, Victoria 3000 (AU) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)