(19)

(11)

EP 4 554 571 A2

(12)

(88) Date of publication A3: 28.03.2024 (43) Date of publication: 21.05.2025 Bulletin 2025/21 (21) Application number: 23840588.0 (22) Date of filing: 14.07.2023

(51) International Patent Classification (IPC):  A61K 31/343(2006.01) C07D 307/93(2006.01) C07D 307/83(2006.01) C07D 405/12(2006.01) (52) Cooperative Patent Classification (CPC): C07D 307/77 (86) International application number: PCT/US2023/070278 (87) International publication number: WO 2024/016000 (18.01.2024 Gazette 2024/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 15.07.2022 US 202263389571 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: SHOKAT, Kevan, M. San Francisco, CA 94143 (US) LOU, Kevin San Francisco, CA 94143 (US) MOORE, Megan, K. San Francisco, CA 94143 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)