(19)

(11)

EP 4 554 625 A1

(12)

(43) Date of publication: 21.05.2025 Bulletin 2025/21 (21) Application number: 23750891.6 (22) Date of filing: 12.07.2023

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 16/30(2006.01) A61P 35/00(2006.01) A61K 47/65(2017.01) (52) Cooperative Patent Classification (CPC): A61K 47/68037; A61K 47/6851; A61K 47/6889; C07K 16/30; A61P 35/00; A61K 47/65; C07K 7/08; C07K 2319/50; C07K 2317/24; C07K 2317/34; C07K 2317/73; A61K 2039/505 (86) International application number: PCT/US2023/070016 (87) International publication number: WO 2024/015830 (18.01.2024 Gazette 2024/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 12.07.2022 US 202263388486 P (71) Applicants: CytomX Therapeutics, Inc. South San Francisco, California 94080 (US) Immunogen, Inc. Waltham, MA 02451 (US)

(72) Inventors: LIU, Bob Y. South San Francisco, California 94080 (US) RANGAN, Vangipuram South San Francisco, California 94080 (US) JING, Chaoran South San Francisco, California 94080 (US) SAHA, Sharmistha South San Francisco, California 94080 (US) WESTIN, Eric Henry Waltham, Massachusetts 02451 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)