(19)

(11)

EP 4 554 794 A1

(12)

(43) Date of publication: 21.05.2025 Bulletin 2025/21 (21) Application number: 23840141.8 (22) Date of filing: 05.07.2023

(51) International Patent Classification (IPC):  B33Y 10/00(2015.01) B33Y 70/00(2020.01) A61L 27/52(2006.01) B33Y 80/00(2015.01) (52) Cooperative Patent Classification (CPC): B33Y 80/00; A61L 27/52; B33Y 70/00; A61L 27/24; A61L 27/3834; A61L 27/3804 (86) International application number: PCT/US2023/026880 (87) International publication number: WO 2024/015237 (18.01.2024 Gazette 2024/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 12.07.2022 US 202217862892 (71) Applicant: University of Louisville Research Foundation, Inc. Louisville, KY 40202-1959 (US)	(72) Inventors: WILLIAMS, Stuart K. Louisville, KY 40202-1959 (US) GETTLER, Brian C. Louisville, KY 40202-1959 (US) GANDHI, Piyani S. Louisville, KY 40202-1959 (US) (74) Representative: Sagittarius IP  Marlow International Parkway Marlow SL7 1YL Marlow SL7 1YL (GB)