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(11)

EP 4 555 074 A1

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(43) Date of publication: 21.05.2025 Bulletin 2025/21 (21) Application number: 23838376.4 (22) Date of filing: 14.07.2023

(51) International Patent Classification (IPC):  C12N 7/00(2006.01) C12N 7/02(2006.01) C12N 7/01(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 31/519; A61K 35/766; C12N 2760/20032; C12N 2760/18432; C12N 2750/14143; C12N 2750/14152; C12N 2710/10332; A61K 31/428; A61K 31/7064   C-Sets: A61K 35/766, A61K 2300/00; (86) International application number: PCT/CA2023/050955 (87) International publication number: WO 2024/011332 (18.01.2024 Gazette 2024/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 14.07.2022 US 202263389064 P (71) Applicant: Ottawa Hospital Research Institute Ottawa, Ontario K1H 8L6 (CA)	(72) Inventors: DIALLO, Jean-simon Ottawa, Ontario K1Z 5N4 (CA) WONG, Boaz Concord, Ontario L4K 3K3 (CA) BERGERON, Anabel Orleans, Ontario K1C 1B1 (CA) ARULANANDAM, Rozanne Orleans, Ontario K1W 0B6 (CA) MAZNYI, Glib Viktorovich Ottawa, Ontario K1V 9N5 (CA) (74) Representative: Lewis Silkin LLP  Arbor 255 Blackfriars Road London SE1 9AX London SE1 9AX (GB)