(19)

(11)

EP 4 558 061 A1

(12)

(43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23843664.6 (22) Date of filing: 19.07.2023

(51) International Patent Classification (IPC):  A61B 17/11(2006.01) A61B 17/08(2006.01) (52) Cooperative Patent Classification (CPC): A61B 17/11; A61B 2017/1107; A61B 2017/1125; A61B 2017/1132; A61B 2017/00876 (86) International application number: PCT/US2023/028164 (87) International publication number: WO 2024/020108 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.07.2022 US 202263390549 P (71) Applicant: Vanderbilt University Nashville, TN 37240 (US)	(72) Inventor: HIGDON, Kent K. Nashville, Tennessee 37240 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)