(19)
(11) EP 4 558 173 A1

(12)

(43) Date of publication:
28.05.2025 Bulletin 2025/22

(21) Application number: 23755291.4

(22) Date of filing: 24.07.2023
(51) International Patent Classification (IPC): 
A61K 47/59(2017.01)
C12N 9/22(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 47/595; C12N 9/22; C12N 15/102; C12N 2310/20
(86) International application number:
PCT/US2023/070818
(87) International publication number:
WO 2024/020597 (25.01.2024 Gazette 2024/04)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
KH MA MD TN

(30) Priority: 22.07.2022 US 202263391598 P

(71) Applicant: The Johns Hopkins University
Baltimore, Maryland 21218 (US)

(72) Inventors:
  • RANGARAMANUJAM, Kannan
    Baltimore, Maryland 21287 (US)
  • LIYANAGE, Wathsala
    Baltimore, Maryland 21287 (US)
  • KANNAN, Sujatha
    Baltimore, Maryland 21287 (US)
  • KANNAN, Gokul
    Highland, Maryland 20777 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) DENDRIMER-ENABLED TARGETED INTRACELLULAR CRISPR/CAS SYSTEM DELIVERY AND GENE EDITING