(19)

(11)

EP 4 558 207 A1

(12)

(43) Date of publication: 28.05.2025 Bulletin 2025/22 (21) Application number: 23843856.8 (22) Date of filing: 19.07.2023

(51) International Patent Classification (IPC):  A61M 25/09(2006.01) A61M 5/00(2006.01) A61M 25/06(2006.01) (52) Cooperative Patent Classification (CPC): A61M 25/09; A61M 2025/09083; A61M 2025/09175 (86) International application number: PCT/US2023/070507 (87) International publication number: WO 2024/020450 (25.01.2024 Gazette 2024/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.07.2022 US 202263390579 P (71) Applicant: Loma Linda University Health Loma Linda, California 92350 (US)	(72) Inventors: GARG, Vinisha Claremont, California 91711 (US) CARRASCO, Heber Riverside, California 92505 (US) (74) Representative: Greaves Brewster LLP  Copa House Station Road Cheddar, Somerset BS27 3AH Cheddar, Somerset BS27 3AH (GB)